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What is Brugada Syndrome?


Brugada Syndrome is a condition in which abnormal sodium channel proteins can result in ventricular arrhythmias and sudden cardiac death in a patient with a structurally normal heart.

It is associated with 3 ECG patterns, the classic being partial/RBBB and ST elevation in the right precordial leads.

Prevalance is estimated at 5 per 10000.
It is commonest in Asians.
Men are 8 to 10 times more affected than women phenotypically, although the genotype prevalence is the same for both genders.
Around 30% of cases are associated with a SCN5A mutation. This is autosomal dominant.


Sudden cardiac death from Brugada is commonest in the 4th decade of life. Around 1 in 5 patients with sudden cardiac death from Brugada would have previously had a syncopal episode. Interestingly arrhythmias associated with Brugada tend to occur during periods of vagal dominance, ie at rest or asleep.


Ajmaline is the ‘best’ drug to unmask Brugada syndrome. Other drugs in use include flecainide and procainamide.



Treatment
a) Avoid precipitants of arrhythmias
- fever
- drugs such as flecainide, ajmaline, procainamide, propafenone, lithium, Tryptizol
b) Use ICD
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